The THEMIS test is based on multimodal epigenetic characterization analysis of cell-free DNA Whole-Methylome Sequencing for early detection and localization of cancer.
THEMIS score, which could yield the final probability of having cancer, is from the ensemble model based on the four modalities by analyzing Whole-Methylome Sequencing (WMS).
THEMIS is a sensitive multicancer detection and localization approach with overall sensitivity of 86% at a specificity of 99%, especially for early-stage cancers showing the sensitivity of 72% (stage I) and 81% (stage II).
Multimodal analysis of cell-free DNA whole methylome sequencing for cancer detection and localization Nature Communications | (2023) 14:6042